Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model

Abstract Background Protein subunit vaccines have a strong track record of efficacy and safety and have been widely applied for prevention of a variety of infectious diseases. The impacts of post-translational modifications of vaccine antigens are often overlooked, despite the fact that they can var...

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Główni autorzy:	Tyler M. Renner, Matthew Stuible, Martin A. Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Janelle Sauvageau, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Frank St. Michael, Jennifer J. Hill, Usha D. Hemraz, Anne E. G. Lenferink, Jamshid Tanha, Barbara Fernandes, Antonio Roldao, Michael J. McCluskie, Bassel Akache, Yves Durocher
Format:	Artigo
Język:	Inglês
Wydane:	Nature Portfolio 2025-04-01
Seria:	Communications Medicine
Dostęp online:	https://doi.org/10.1038/s43856-025-00830-w
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