Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation

Using SNP-based microarray data from The Cancer Genome Atlas (TCGA), we investigated isochromosomes (deletion of one arm and duplication of the other arm) and related acquired uniparental disomy in 12 tumor types. We observed a high frequency of isochromosomes (25.98%) across all type of tumors exce...

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Hlavní autoři:	Musaffe Tuna, Christopher I. Amos, Gordon B. Mills
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2022-03-01
Edice:	Neoplasia: An International Journal for Oncology Research
Témata:	Acquired uniparental disomy Isochromosomes Whole-chromosome arm Cancers DNA double-strand breaks TP53
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1476558621001135
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