Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer’s disease (AD). Strategies to regulate P-gp expression therefore may impact central nervous system (CNS) drug deliv...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jae Pyun, HuiJing Koay, Pranav Runwal, Celeste Mawal, Ashley I. Bush, Yijun Pan, Paul S. Donnelly, Jennifer L. Short, Joseph A. Nicolazzo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-08-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	blood-brain barrier P-glycoprotein copper bis(thiosemicarbazone) CNS drug delivery
Online-Zugang:	https://www.mdpi.com/1999-4923/15/8/2084
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!