Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

Abstract Background Alcohol use disorder (AUD) has been associated with Alzheimer’s disease (AD) and dementia, yet the underlying mechanisms and specific role of ethanol in AD progression remain poorly understood. Neuroinflammation has emerged as a key contributor to both AD pathogenesis and ethanol...

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Autori principali:	Veronika Brezani, Radhika S. Joshi, Marti Ortega-Ribera, Prashanth Thevkar Nagesh, Viliam Brezani, Adam Zivny, Evelyn A. Kurt-Jones, Douglas T. Golenbock, Gyongyi Szabo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-07-01
Serie:	Journal of Neuroinflammation
Soggetti:	Alzheimer’s Alcohol use disorder Ethanol Neuroinflammation Inflammasome ASC specks
Accesso online:	https://doi.org/10.1186/s12974-025-03501-8
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