Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Abstract Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported t...

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Bibliografische Detailangaben

Hauptverfasser:	Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2021-05-01
Schriftenreihe:	Molecular Brain
Schlagworte:	GBA1 GBA2 Gaucher’s disease Parkinson’s disease α-Synuclein Glucocerebrosidase
Online-Zugang:	https://doi.org/10.1186/s13041-021-00790-x
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