Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans

Abstract Cancer research in veterinary medicine is still under development compared to human medicine. Feline breast cancer (FBC) is highly malignant, intractable, and has the potential to become a valuable model for human metastatic BC (HBC). We developed primary FBC organoids and analyzed their mo...

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Principais autores:	Haru Yamamoto, Mohamed Elbadawy, Ryouichi Tsunedomi, Noriko Maeda, Hiroaki Nagano, Yusuke Ishihara, Amira Abugomaa, Yomogi Shiota, Ting-Wei Yu, Yishan Liu, Yuko Nagashima, Yuki Kobayashi, Riho Matsui, Suzuka Uomoto, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Tetsuya Kobayashi, Mai Inoue, Midori Higashinaka, Ryuji Fukushima, Daigo Azakami, Tsuyoshi Uchide, Yuta Shinohara, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-11-01
Serija:	Scientific Reports
Teme:	Breast cancer Feline mammary tumor LMTK3 FADS2 Organoids
Online dostop:	https://doi.org/10.1038/s41598-025-28751-7
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