A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput selection and screening process that identifies designed ankyrin repeat proteins (DARPins) optimally suited for receptor-targeted gene delivery us...

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Detalles Bibliográficos

Principais autores:	Jessica Hartmann, Robert C. Münch, Ruth-Therese Freiling, Irene C. Schneider, Birgit Dreier, Washington Samukange, Joachim Koch, Markus A. Seeger, Andreas Plückthun, Christian J. Buchholz
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2018-09-01
Series:	Molecular Therapy: Methods & Clinical Development
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2329050118300640
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