In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening

Abstract The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potential therapeutic target to treat hypertension. In o...

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Hlavní autoři:	Maxime Louet, Sara Bitam, Naziha Bakouh, Yohan Bignon, Gabrielle Planelles, David Lagorce, Maria A. Miteva, Dominique Eladari, Jacques Teulon, Bruno O. Villoutreix
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2017-08-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-017-07794-5
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