Utilizing partial information decomposition to evaluate the complex interplay between microRNA and RNA-binding protein in regulating the shared target mRNA

Abstract MicroRNAs (miRNAs) bind to the 3′ untranslated region of mRNA transcripts, exerting inhibitory activity over gene expression. RNA-binding proteins (RBPs) involved in post-transcriptional regulation also play a pivotal role in modulating mRNA, exhibiting similar binding and regulatory effect...

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Bibliografische Detailangaben

Hauptverfasser:	Tianwu Zhang, Yanlin Chen, Wenrong Wang, Chu Pan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-09-01
Schriftenreihe:	Scientific Reports
Schlagworte:	microRNAs RNA-binding proteins Cooperative and competitive regulatory relationship Partial information decomposition
Online-Zugang:	https://doi.org/10.1038/s41598-025-17031-z
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