Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin

PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for drug development. However, most PROTACs generated lack cell-type selectivity and are poorly soluble in water. To address this d...

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Auteurs principaux:	Lin Zhang, Ling Li, Xia Wang, Huimin Liu, Yibin Zhang, Tiantian Xie, Hui Zhang, Xiaodong Li, Tianhuan Peng, Xing Sun, Jing Dai, Jing Liu, Wencan Wu, Mao Ye, Weihong Tan
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-12-01
Collection:	Molecular Therapy: Nucleic Acids
Sujets:	MT: Oligonucleotides: Therapies and Applications aptamer PROTAC nucleolin degradation ubiquitination
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2162253122002517
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