Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
<p>Abstract</p> <p>Background</p> <p>A mutation in the <it>BRI2/ITM2b</it> gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis. The FDD mutation leads to a loss of BRI2...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2012-04-01
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| coleção: | Molecular Neurodegeneration |
| Acesso em linha: | http://www.molecularneurodegeneration.com/content/7/1/19 |
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