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Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts

Summary: Cardiovascular disease risk is elevated in patients with cirrhosis. However, the underlying molecular mechanisms remain poorly understood. Herein, we found that high levels of circulating transforming growth factor (TGF)-β1 were associated with an increased risk of cardiomyopathy in cirrhos...

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Principais autores: He Sun, MD, Kai Song, PhD, Ze-Yu Zhou, PhD, Bin Tu, PhD, Yang Zhou, PhD, Li-Chan Lin, MD, Zhi-Yan Liu, MD, Zhen-Yu Liu, MD, Ji-Ming Sha, PhD, Yan Shi, PhD, Jing-Jing Yang, PhD, Dong Lu, PhD, Jian-Yuan Zhao, PhD, Hui Tao, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:JACC: Basic to Translational Science
Fag:
cardiac fibrosis
cirrhosis
DNA methylation
Notch1
transforming growth factor-β1
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452302X24004546
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