Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer typesResearch in context

Summary: Background: Mitochondrial dysfunction is a hallmark of cancer. However, it is unclear whether it is a cause of cancer. This two-sample Mendelian randomization (MR) analyses, uses genetic instruments to proxy the exposure of mitochondrial dysfunction and cancer summary statistics as outcome...

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Autors principals:	Yanni Li, Kristina Sundquist, Naiqi Zhang, Xiao Wang, Jan Sundquist, Ashfaque A. Memon
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-02-01
Col·lecció:	EBioMedicine
Matèries:	Mendelian randomization Mitochondrial dysfunction Cancers Colocalization Pharmaceutical targets
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2352396422006144
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