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Targeting Pro-Oxidant Iron with Deferoxamine as a Treatment for Ischemic Stroke: Safety and Optimal Dose Selection in a Randomized Clinical Trial

A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. Ferroptosis is a new form o...

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Principais autores: Mònica Millán, Núria DeGregorio-Rocasolano, Natàlia Pérez de la Ossa, Sílvia Reverté, Joan Costa, Pilar Giner, Yolanda Silva, Tomás Sobrino, Manuel Rodríguez-Yáñez, Florentino Nombela, Francisco Campos, Joaquín Serena, José Vivancos, Octavi Martí-Sistac, Jordi Cortés, Antoni Dávalos, Teresa Gasull
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-08-01
coleção:Antioxidants
Assuntos:
iron
deferoxamine
antioxidant
ferroptosis
neuroprotection
outcome
Acesso em linha:https://www.mdpi.com/2076-3921/10/8/1270
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