Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated H2S-albumin thiol antioxidant network

Acetaminophen (APAP) overdose is the leading cause of acute liver failure and a major global health issue. APAP hepatotoxicity is primarily driven by oxidative stress resulting from the depletion of hepatic glutathione (GSH). Given that hydrogen sulfide (H2S) and albumin are crucial components of th...

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Detalhes bibliográficos

Principais autores:	Xin Wang, Yang Sui, Rui Jiang, Yijun Xu, Mika Suda, Jie Cheng, Yingyu Zhang, Zhuheng Shi, Jianglin Fan, Jian Yao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Redox Biology
Assuntos:	APAP-Induced liver injury (AILI) Oxidative stress Hydrogen sulfide Sulfhydrylated albumin Thiol antioxidant Glutathione
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231725002873
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