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Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels

Abstract Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemortem plasma p-tau levels remains critical to understa...

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Principais autores: Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val J. Lowe, Jeffrey L. Dage, Ronald C. Petersen, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M. Mielke
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-12-01
Serier:Molecular Neurodegeneration
Fag:
Alzheimer’s Disease
Neuropathology
Blood biomarker
Phosphorylated Tau
Neurofibrillary Tangles
Amyloid-β
Online adgang:https://doi.org/10.1186/s13024-022-00578-0
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