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Antigen-Presenting B Cells Program the Efferent Lymph T Helper Cell Response

B cells interact with T follicular helper (Tfh) cells in germinal centers (GCs) to generate high-affinity antibodies. Much less is known about how cognate T–B-cell interactions influence Th cells that enter circulation and peripheral tissues. Therefore, we generated mice lacking MHC-II expressing B...

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Main Authors: Samuel Alsén, Jakob Cervin, Yaxiong Deng, Louis Szeponik, Ulf Alexander Wenzel, Joakim Karlsson, Helena Cucak, Megan Livingston, David Bryder, Qianjin Lu, Bengt Johansson-Lindbom, Ulf Yrlid
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
efferent lymph
T cells
B cells
gut-homing CD4+ T cells
small intestinal lamina propria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.813203/full
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