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The SNAP-25 linker supports fusion intermediates by local lipid interactions

SNAP-25 is an essential component of SNARE complexes driving fast Ca2+-dependent exocytosis. Yet, the functional implications of the tandem-like structure of SNAP-25 are unclear. Here, we have investigated the mechanistic role of the acylated “linker” domain that concatenates the two SNARE motifs wi...

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Principais autores: Ahmed Shaaban, Madhurima Dhara, Walentina Frisch, Ali Harb, Ali H Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2019-03-01
Serier:eLife
Fag:
exocytosis
SNARE complex
SNAP-25
fusion pore
fusion triggering
chromaffin cells
Online adgang:https://elifesciences.org/articles/41720
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