Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in t...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2015-09-01
Sarja:	eLife
Aiheet:	MRSA ROS NO S. typhimurium Mycobacterium tuberculosis pathogenic bacteria
Linkit:	https://elifesciences.org/articles/06508
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