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Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells.

Rickettsia (R.) typhi is the causative agent of endemic typhus, an emerging febrile disease that is associated with complications such as pneumonia, encephalitis and liver dysfunction. To elucidate how innate immune mechanisms contribute to defense and pathology we here analyzed R. typhi infection o...

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Bibliografische Detailangaben
Hauptverfasser: Stefanie Papp, Kristin Moderzynski, Jessica Rauch, Liza Heine, Svenja Kuehl, Ulricke Richardt, Heidelinde Mueller, Bernhard Fleischer, Anke Osterloh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2016-08-01
Schriftenreihe:PLoS Neglected Tropical Diseases
Online-Zugang:http://europepmc.org/articles/PMC4993389?pdf=render
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