Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD

Alzheimer’s disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running behavior both early and late in disease progression i...

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Principais autores:	Stephen L. P. Lippi, Peter A. Kakalec, Meghann L. Smith, Jane M. Flinn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-08-01
coleção:	Frontiers in Neuroscience
Assuntos:	zinc circadian activity Alzheimer’s disease mouse model sex age
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnins.2020.00854/full
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