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Evaluation of In Vitro Inhibition of <i>β</i>-Hematin Formation: A Step Towards a Comprehensive Understanding of the Mechanism of Action of New Arylamino Alcohols

Currently, artemisinin-based combination therapy is recommended as first-line treatment of uncomplicated <i>falciparum</i> malaria. Arylamino alcohols (AAAs) such as mefloquine (MQ) are the preferred partner drugs due to their longer half-life, reliable absorption and strong antimalarial activity. H...

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Principais autores: Céline Damiani, Floriane Soler, Yohann Le Govic, Anne Totet, Guillaume Bentzinger, Anne Bouchut, Romain Mustière, Patrice Agnamey, Alexandra Dassonville-Klimpt, Pascal Sonnet
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Microorganisms
Fag:
<i>Plasmodium falciparum</i>
hemozoin
<i>β</i>-hematin
cytotoxicity
arylamino alcohols
mechanisms of action
Online adgang:https://www.mdpi.com/2076-2607/12/12/2524
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