Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

Abstract Tumor cells often cope with elevated levels of replication stress (RS) causing increased dependency on ATR-CHK1 signaling. We previously presented RRM2, the regulatory component of the ribonucleotide reductase (RNR) enzyme, as novel dependency in neuroblastoma (NB), in keeping with its role...

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Auteurs principaux:	Iris H. Nelen, Soetkin Leys, Sarah-Lee Bekaert, Fanny De Vloed, Fien Martens, Ellen Sanders, Angeline Praveena Enton Raj, Annika Jeschke, Shunya Ohmura, Thomas G. P. Grünewald, Liselot M. Mus, Tim Lammens, Nadine Van Roy, Bram De Wilde, Frank Speleman, Annelies Van Hemelryk, Lisa Depestel, Kaat Durinck
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2026-02-01
Collection:	Cell Death and Disease
Accès en ligne:	https://doi.org/10.1038/s41419-026-08514-6
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