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Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for hyperemesis gravidarum

Abstract Background Hyperemesis gravidarum (HG), excessive vomiting in pregnancy, occurs in 0.3–10.8% of pregnancies and is associated with maternal and fetal morbidity. Despite the existence of several off-label treatment options that have shown clinical effectiveness in managing HG symptoms, the v...

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Hlavní autoři: Fengyang Wang, Wenpeng Ruan, Qiuyuan Yin, Lei Zhu
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-12-01
Edice:BMC Pregnancy and Childbirth
Témata:
Hyperemesis gravidarum
Mendelian randomization
Drug target
On-line přístup:https://doi.org/10.1186/s12884-024-07077-8
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