Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis

Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS), remains challenging. Chromosome conformation ca...

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Autori principali:	Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Julian C. Knight, Matteo Vecellio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-01-01
Serie:	Frontiers in Genetics
Soggetti:	genomics three dimensional genome ankylosing spondylitis chromosome conformation capture (3C) topologically associated domain (TAD) rheumatic and musculoskeletal disease
Accesso online:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1129207/full
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