The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that evolve during aging in physiological and dise...

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Hauptverfasser:	Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-07-01
Schriftenreihe:	iScience
Schlagworte:	Neuroscience Molecular Neuroscience Cellular Neuroscience
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004220304417
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