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HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells

ABSTRACT HIV-1 Vpr has a major impact on the cellular transcriptome and proteome. Although Vpr is known to stimulate the nuclear factor of activated T cells (NFAT), it remained unclear to what extent transcriptional changes induced by Vpr are governed by NFAT. We, therefore, performed RNA sequencing...

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Principais autores: Johanna Leyens, Carlos Alberto Vanegas-Torres, Anthea Darius, Rabea Seizer, Brigitta Maurer, Daniel Sauter, Rishikesh Lotke, Michael Schindler
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-03-01
Serier:mBio
Fag:
HIV-1
Vpr
NFAT
transcriptional network
G2 arrest
cell cycle
Online adgang:https://journals.asm.org/doi/10.1128/mbio.03605-25
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