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Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population

Background: Asthma exacerbations are episodes of symptom worsening requiring increased therapy, which affect patients across all asthma severities. Potential genetic associations with asthma exacerbations in an understudied population were investigated. Objective: We sought to perform a genome-wide...

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Principais autores: Maria B.R. de Santana, PhD, Álvaro A. Cruz, MD, Helena M.P. Teixeira, PhD, Hatilla dos S. Silva, MSc, Mahmoud I. Abdel-Aziz, PhD, Simone Hashimoto, MD, Susanne J.H. Vijverberg, PhD, Esther Herrera-Luis, PhD, Maria Pino-Yanes, PhD, Esteban G. Burchard, PhD, Kian Fan Chung, MD, Ratko Djukanovic, MD, Sven-Erik Dahlén, MD, Ian M. Adcock, PhD, Corey Cox, MD, Tonya Brunetti, PhD, Monica Campbell, MS, Nicholas Rafaels, Kathleen C. Barnes, PhD, Anke H. Maitland-van der Zee, PhD, Camila A. Figueiredo, PhD, Ryan S. Costa, PhD
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Assuntos:
Asthma
GWAS
genetic variants
severe asthma exacerbations
viral respiratory infections
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2772829325001080
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