Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine

SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2−/−) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2−/− mice had reduced expression of genes requir...

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Autores principales:	Shunxing Rong, Jeffrey G. McDonald, Luke J. Engelking
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2017-10-01
Colección:	Journal of Lipid Research
Materias:	SREBP Scap cholesterol/biosynthesis fatty acid/synthesis Niemann-Pick C1-like 1 organoid
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227520335690
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