A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium levels and generating reactive oxygen species....
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| Auteurs principaux: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2021-01-01
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| Collection: | Communications Biology |
| Accès en ligne: | https://doi.org/10.1038/s42003-020-01490-3 |
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