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Effect of 3-hydroxyisobutyrate in vivo administration on cardiometabolic disease in ApoE-/- mouse model

The valine catabolite 3-hydroxyisobutyrate (3-HIB) is suggested to mediate the uptake of extracellular fatty acids into the cells, thus regulating intracellular lipid metabolism, although the direct mechanism remains unclear. In this study, we assessed the effects of long-term 3-HIB treatment on the...

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Principais autores: Viviana Casagrande, Luca Panarello, Alessio Lepri, Andrea Quatrana, Chiara Internò, Lorenzo Antonetti, Elena Bonanno, Ilaria Cicalini, Damiana Pieragostino, Andrea Gorgels, Vincenzo De Laurenzi, Claudia Goettsch, Marina Cardellini, Massimo Federici, Rossella Menghini
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Pharmacological Research
Fag:
Atherosclerosis
Lipid metabolism
3-hydroxyisobutyrate
Fatty acid oxidation
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661825003688
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