Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver

Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death. In addition, this enzyme appears to play a role in the progression...

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Bibliografiske detaljer

Principais autores:	Julie Massart, Karima Begriche, Jessica H. Hartman, Bernard Fromenty
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2022-01-01
Serier:	Cells
Fag:	mitochondria cytochrome P450 2E1 alcohol-associated liver disease drug-induced liver injury nonalcoholic fatty liver disease
Online adgang:	https://www.mdpi.com/2073-4409/11/2/288
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