PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both tumor progression and tumor suppression. For ex...

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Автори:	Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V Katlinskaya, Kirk A Staschke, Maria C G Paredes, Akihiro Yoshida, Shuo Qie, Gao Zhang, Olga S Chajewski, Lawrence Wu, Ireneusz Majsterek, Meenhard Herlyn, Serge Y Fuchs, J Alan Diehl
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2016-12-01
Серія:	PLoS Genetics
Онлайн доступ:	http://europepmc.org/articles/PMC5207760?pdf=render
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