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Chronic modafinil therapy ameliorates depressive-like behavior, spatial memory and hippocampal plasticity impairments, and sleep-wake changes in a surgical mouse model of menopause

Abstract Depression, cognitive deficits, and sleep disturbances are common and often severe in menopausal women. Hormone replacement cannot effectively alleviate these symptoms and sometimes elicits life-threatening adverse reactions. Exploring effective therapies to target psychological problems is...

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Principais autores: Yu-Dong Yan, Yu-Qing Chen, Chen-Yao Wang, Chen-Bo Ye, Zhen-Zhen Hu, Thomas Behnisch, Zhi-Li Huang, Su-Rong Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2021-02-01
coleção:Translational Psychiatry
Acesso em linha:https://doi.org/10.1038/s41398-021-01229-6
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