Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells

Summary: Generation of chimeric antigen receptor (CAR) T cells from pluripotent stem cells (PSCs) will enable advances in cancer immunotherapy. Understanding how CARs affect T cell differentiation from PSCs is important for this effort. The recently described artificial thymic organoid (ATO) system...

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Autori principali:	Suwen Li, Chloe S. Wang, Amélie Montel-Hagen, Ho-Chung Chen, Shawn Lopez, Olivia Zhou, Kristy Dai, Steven Tsai, William Satyadi, Carlos Botero, Claudia Wong, David Casero, Gay M. Crooks, Christopher S. Seet
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2023-03-01
Serie:	Cell Reports
Soggetti:	CP: Immunology CP: Stem cell research
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124723002528
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