Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Abstract Polyploidy is a common outcome of chemotherapies, but there is conflicting evidence as to whether polyploidy is an adverse, benign or even favourable outcome. We show Aurora B kinase inhibitors efficiently promote polyploidy in many cell types, resulting in the cell cycle exit in RB and p53...

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Egile Nagusiak:	Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2025-01-01
Saila:	Cell Death and Disease
Sarrera elektronikoa:	https://doi.org/10.1038/s41419-024-07329-7
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