Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk

Pro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrhosis, indicating that a new hemostatic balance is reached. TG is determined by prothrombin conversion a...

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Bibliografische Detailangaben

Hauptverfasser:	Ruth Anne Laura Willems, Alberto Zanetto, Elena Campello, Joke Konings, Cristiana Bulato, Matthijs Kramer, Francesco Paolo Russo, Mark Roest, Marco Senzolo, Patrizia Burra, Hugo ten Cate, Judith de Vos-Geelen, Bas de Laat, Paolo Simioni, Romy de Laat-Kremers
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-09-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	bleeding cirrhosis prothrombin conversion thrombin generation thrombosis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1764080/full
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