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Production of functional CD19 CAR T cells under hypoxic manufacturing conditions

IntroductionChronic lymphocytic leukemia (CLL) has proven difficult to treat with chimeric antigen receptor (CAR) T cell therapy. CLL cells can negatively alter T cell fitness and induce a pseudohypoxic state. We hypothesized that production of CAR T cells under restricted oxygen conditions resembli...

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Hoofdauteurs: Isabella Micallef Nilsson, Thomas Poiret, Jinhye Ryu, Mohammadali Mohammadpour, Johan Henriksson, Anders Österborg, Jonas Mattsson, Anna Schurich, Isabelle Magalhaes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2025-10-01
Reeks:Frontiers in Immunology
Onderwerpen:
CAR T cells
hypoxia
CLL (chronic lymphocytic leukemia)
tumor microenvironment
mitochondria
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1675786/full
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