LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. Using huma...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical investigation
2023-07-01
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| Serie: | JCI Insight |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1172/jci.insight.167310 |
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