Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model

Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. Heterozygous loss-of-function mutations in TREM2, including mutations enhancing shedding form the cell surface, have been associate...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R. Shimshek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-02-01
coleção:	Journal of Neuroinflammation
Assuntos:	TREM2 Microglia Neuroinflammation Phagocytosis Cuprizone MRI
Acesso em linha:	https://doi.org/10.1186/s12974-022-02671-z
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!