Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer’s disease and multi-etiology dementia

Abstract Background Up to 80% of Alzheimer’s disease (AD) patients suffer from brain vascular damage resulting in multi-etiology dementia (MED). Sex is a well-known risk factor for dementia; out of three AD patients two are women. 17β-estradiol, a predominant ovarian hormone in woman before menopaus...

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Hlavní autoři:	Charly Abi-Ghanem, Alex K. Opiela, Aaron S. Paul, McKenzie L. Comito, Lawrence Hao, Grace Martino, Nyi-Rein Kyaw, Abigail E. Salinero, Febronia M. Mansour, Richard D. Kelly, Ann M. Mutahi, Avi Sura, Christina A. Thrasher, Emily A. Groom, Molly R. Batchelder, Kristen L. Zuloaga
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	Biology of Sex Differences
Témata:	Alzheimer’s disease Multi-etiology dementia Menopause Estrogen Ovariectomy Cognitive decline
On-line přístup:	https://doi.org/10.1186/s13293-025-00795-4
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