Refined single-cell profiling captures a CCR5high CD4+ cytotoxic T-cell precursor in multiple sclerosisResearch in context

Summary: Background: Decades of immunological and genetic studies highlight CD4+ T cells as initiators of central nervous system (CNS) pathology in individuals who develop multiple sclerosis (MS). A low-frequency CD4+ T-cell population termed T helper 17.1 (Th17.1) has been argued to play a central...

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Autori principali:	Fabiënne van Puijfelik, Jasper Rip, Yifan van Hasselt, Annet F. Wierenga-Wolf, Sophie Shyfrin, Anna C. Pelser, Marie-Jose Melief, Romy A.M. Klein Kranenbarg, Eric M. Bindels, Harmen J.G. van de Werken, Chaja M.J. van Ansenwoude, Helga E. de Vries, Willem A. Dik, Janet de Beukelaar, Ide Smets, Beatrijs H. Wokke, Joost Smolders, Marvin M. van Luijn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-07-01
Serie:	EBioMedicine
Soggetti:	Multiple sclerosis (MS) CD4+ T cell Cytotoxic T lymphocytes (CTL) Th17.1 cells CCR5 Single-cell RNA sequencing (scRNA-seq)
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352396426002069
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