Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

Volume-regulated anion channels (VRACs) are heteromers of LRRC8 proteins, all containing the obligatory subunit LRRC8A. Here, the authors develop and characterize nanobodies that bind LRRC8A and allosterically modulate the function of homomeric LRRC8A and endogenous heteromeric channels, hinting at...

Descripció completa

Dades bibliogràfiques

Autors principals:	Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2021-09-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-021-25742-w
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!