Bayesian modeling reveals metabolite‐dependent ultrasensitivity in the cyanobacterial circadian clock

Abstract Mathematical models can enable a predictive understanding of mechanism in cell biology by quantitatively describing complex networks of interactions, but such models are often poorly constrained by available data. Owing to its relative biochemical simplicity, the core circadian oscillator i...

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Autori principali:	Lu Hong, Danylo O Lavrentovich, Archana Chavan, Eugene Leypunskiy, Eileen Li, Charles Matthews, Andy LiWang, Michael J Rust, Aaron R Dinner
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2020-06-01
Serie:	Molecular Systems Biology
Soggetti:	Bayes factor kinetic modeling Markov chain Monte Carlo robustness substrate competition
Accesso online:	https://doi.org/10.15252/msb.20199355
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