Monotropein inhibits epithelial–mesenchymal transition in chronic colitis via the mTOR/P70S6K pathway

IntroductionPatients with chronic colitis are at risk of developing intestinal fibrosis through epithelial–mesenchymal transition (EMT). Monotropein (MON) is the main active ingredient in the traditional Chinese medicine Morinda officinalis How. It has been reported that monotropein can improve ulce...

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Autors principals:	Yuanfan Chen, Jiaying Liu, Shaowen Zhong, Tianwu Zhang, Jin Yuan, Jing Zhang, Ying Chen, Jian Liang, Yonger Chen, Shaozhen Hou, Haiyang Huang, Jie Gao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-02-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	monotropein DSS epithelial–mesenchymal transition mTOR/P70S6K chronic colitis
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1536091/full
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