A novel strategy for secretory leukocyte protease inhibitor (SLPI) immobilization on alkaline-etched titanium via a plasma-polymerized interlayer and covalent coupling to enhance osteoblast activity

Abstract Titanium (Ti) implants are the gold standard for orthopedic and dental applications, but their bioinert surfaces lack the osteoinductive properties. Combining alkaline etching for biomimetic surface topography and biofunctionalization with secretory leukocyte protease inhibitor (SLPI) has p...

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Principais autores:	Wannapat Chouyratchakarn, Wei-Yu Chen, Nithi Atthi, Chayarop Supanchart, Sarawut Kumphune
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-04-01
Colecção:	Scientific Reports
Assuntos:	Plasma polymerization NaOH etching Secretory leukocyte protease inhibitor Surface modification Osteoblast adhesion Differentiation
Acesso em linha:	https://doi.org/10.1038/s41598-026-48469-4
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