Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider alternative sources to expand the repertoire of tar...

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Autori principali:	Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-03-01
Serie:	Scientific Reports
Soggetti:	Glioma Alternative splicing Antigen Neojunction Bulk RNA-sequencing Long-read sequencing
Accesso online:	https://doi.org/10.1038/s41598-024-56684-0
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