A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats

Mammary tumors are the most prevalent type of tumors in female dogs. Breast cancer 2, early onset (<i>BRCA2</i>) malignant mutations are associated with tumorigenesis in humans and dogs. BRCA2 plays a pivotal role in homologous recombination repair by recruiting RAD51 recombinase to DNA damage sites...

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Hlavní autoři:	Zida Zhu, Taisuke Kitano, Masami Morimatsu, Kazuhiko Ochiai, Toshina Ishiguro-Oonuma, Kosuke Oosumi, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-02-01
Edice:	Veterinary Sciences
Témata:	BRCA2 RAD51 BRC repeats highly conserved region comparative molecular biology mutation analysis
On-line přístup:	https://www.mdpi.com/2306-7381/10/2/145
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