Establishing selectivity of FAK-paxillin PPI inhibitor using pulldown proteomics and a focal adhesion protein selectivity panel

UA-2012 (and related non-myristoylated analog UA-1907) is a lead alpha-helical cyclic peptide which inhibits the focal adhesion kinase (FAK)-paxillin protein-protein interaction (PPI) and is being evaluated for the treatment of cutaneous melanoma. However, the development of an empirical approach to...

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Autori principali:	Hunter O'Brien, Brock Hay, Huzaifah Sheikh, Liam McCreary, Krishna Parsawar, Timothy Marlowe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Biochemistry and Biophysics Reports
Soggetti:	Surface plasmon resonance Interactome Proteomics Mass spectrometry Drug selectivity Peptide therapeutic
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2405580825004972
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