Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.

The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwise viral diversity as a proxy for time since infect...

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Principais autores:	Nadia Neuner-Jehle, Marius Zeeb, Christian W Thorball, Jacques Fellay, Karin J Metzner, Paul Frischknecht, Kathrin Neumann, Christine Leeman, Andri Rauch, Marcel Stöckle, Michael Huber, Matthieu Perreau, Enos Bernasconi, Julia Notter, Matthias Hoffmann, Karoline Leuzinger, Huldrych F Günthard, Chloé Pasin, Roger D Kouyos, Swiss HIV Cohort Study (SHCS)
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2024-08-01
סדרה:	PLoS Pathogens
גישה מקוונת:	https://doi.org/10.1371/journal.ppat.1012385
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